primers for pyrosequencing slc6a4 and tph2 (Pyrosequencing Inc)
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Primers For Pyrosequencing Slc6a4 And Tph2, supplied by Pyrosequencing Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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1) Product Images from "No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state"
Article Title: No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state
Journal: Clinical Epigenetics
doi: 10.1186/s13148-024-01678-y
Figure Legend Snippet: Overview of the data and methods used in this study. a , b , c , d depict the primary analyses, in which a latent variable model was used to determine the association between peripheral TPH2 and SLC6A4 methylation and brain levels of 5-HTT and 5-HT 4 . e , f , g describe the sensitivity analyses evaluating the association between SLC6A4 / TPH2 methylation and measures of environmental stress, depressive and anxiety symptoms. h and i show sensitivity analyses used to evaluate potential influence of blood cell proportions in the A-G analyses. Abbreviations: 5-HT 4 : serotonin 4 receptor; 5-HTT: serotonin transporter; CpG: CpG site; TSS: transcription start site; SLE: stressful life events; PBI: parental bonding inventory; BDI: Beck’s depressive index; GAD10: generalized anxiety disorder 10-item; CATS: childhood abuse trauma scale; HAMD6: Hamilton depressive rating scale 6; PSS: perceived stress scale; CpG LV : latent variable including all CpG methylation values
Techniques Used: Methylation, CpG Methylation Assay
Figure Legend Snippet: Demographics of the participants included in the primary analyses
Techniques Used: Methylation
Figure Legend Snippet: Associations between peripheral TPH2 DNA methylation and brain 5-HTT binding a or 5-HT 4 binding b in the healthy cohort. Orange dashed boxes to the left depict the TPH2 CpG sites and the covariates included in the model. Rs45706210 stands for TPH2 rs45706210 G/T SNP. For representation purposes, PET and MR scanner covariates are not reported in the a and b models. Similarly, although included in the 5-HT 4 latent variable model, 5-HTTLPR/rs25531 and BDNF rs6265 genotypes are not reported in ( b ). Scatter plots in c and d depict the relation between TPH2 methylation and 5-HTT LV or 5-HT 4LV in healthy controls ( c , d ), while the relation between TPH2 methylation and 5-HT 4 binding in patients with MDD is showed in ( e )
Techniques Used: DNA Methylation Assay, Binding Assay, Methylation
Figure Legend Snippet: Results of latent variable models (LVM) evaluating the association between SLC6A4 / TPH2 methylation and 5-HTT and 5-HT 4 brain binding
Techniques Used: Methylation
Figure Legend Snippet: Association between a latent variable including blood cell proportions (CpG LV+cells ) and a latent variable including serotonin transporter (5-HTT) or serotonin 4 receptor (5-HT 4 ) binding
Techniques Used: